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Is there any interaction between CBD and other medications?

Dr. Med. Vladimir Krasula


June 4, 2021

One of the biggest concerns customers considering taking CBD are drug interactions and if CBD is safe to take with other medications to treat diseases and various conditions. While CBD can deliver a variety of benefits to human and animal body and is safe to take with many medications, CBD can also worsen some side effects of drugs.

When you take a medication or other substance and supplements, your body has to metabolize them, which is happening in the liver mainly.

CBD inhibits some liver enzymes called CYP450. This makes them break down certain drugs more slowly, which could potentially increase side effects. Grapefruit disrupts the activity of CYPs enzymes and slows the way these proteins usually break down medication, it also increases the side effects and duration the drug stays in your system.

You may experience increased side effects if CBD is used along with these drugs:

  • Antidepressants – fluoxetine or Prozac
  • Antipsychotics, benzodiazepines
  • Macrolide antibiotics – erythromycin
  • Some heart medications

We advise you before trying CBD to talk to your doctor about all of the vitamins, supplements and prescription you’re taking.

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